Some Aspects of Dosage, Clinical Selectivity and Stereoisomerism

Some Aspects of Dosage, Clinical Selectivity and Stereoisomerism 

Dosage rate is defined as the systemically available dose divided by the dosage interval 

Assuming knowledge of the systemic clearance and the desired average steady-state plasma concentration of a drug, the dosage rate can be calculated from 

Systemic clearance, which measures the ability of the body to eliminate a drug, determines the relationship between the dosage rate and the average steady-state plasma concentration. When multiple (fixed) doses of a drug are administered at a constant dosage interval (r) the average plasma concentration that will be attained at steady-state can be predicted  

Because the area under the plasma drug concentration-time curve during a dosage interval at steady-state is equal to the total area under the curve after administering a single intravenous dose, the average plasma concentration at steady-state can be estimated from 

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