Somatostatin Receptor Agonists Treatment of Excess Gastrointestinal Secretion

Somatostatin Receptor Agonists Treatment of Excess Gastrointestinal Secretion 

Title Hydantoin Derivatives with Affinity for Somatostatin Receptors D. Berney et al., US Patent 7,019,004 (March 28, 2006) 

Invention Significance Somatostatin directly impacts the inhibition of 

Preparation of /V-a-/-butyloxycarbonyl-D,L-tryptophan-[5-amino-(/V-l-butyloxy carbonyl)- -pentanyl] amide 

A stirred solution of mono-A-Boc-l,5-pentanediamine (6.3 mmol) and D,L-tryptophan (7.0 mmol) in 30 ml THF was treated with dicyclohexylcarbodiimide (7.5 mmol) at ambient temperature and stirred 1 hour. The mixture was filtered, concentrated, and warm diethyl ether added to the residue. Upon cooling, crystallization occurred and the product isolated as a light brown powder, mp = 97-98°C. 

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I. Somatostatin Receptor Agonists Treatment of Excess Gastrointestinal Secretion... 

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