Somatostatin receptor agonist

I. Somatostatin Receptor Agonists Treatment of Excess Gastrointestinal Secretion... 

Spiro hydantoins, (III) prepared by Webb (4) and hydantoin and thiohydantoin, (IV), derivatives prepared by Poitout (5) were effective as somatostatin receptor agonists and were useful in treating hypersecretion disorders. 

Figure 15.33. Somatostatin receptor agonists found through combinatorial chemistry.

S.P. Rohrer, J.M. Schaeffer, Identification and characterization of subtype selective somatostatin receptor agonists, J. Physiol. 2000, 94, 211-215. 

Chemical genetic screens have identified several small molecules targeting a TGF- i-responsive reporter gene, arresting mammalian cells in mitosis, uihibiting the function of tumor suppressor p53, and acting as subtype-selective somatostatin receptor agonist. 

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