Solvents for NMR

Solvents for NMR Spectroscopy, NMR spectra are almost invariably obtained in... 

Detection methods, in stability studies, 12, 621 Deuterated solvents, for NMR of air-sensitive compounds,... 

FIGURE 3 Typical metabolomics workflow. Biological samples are quenched, for example, with liquid nitrogen to stop enzymatic reactions. Afterward, they are extracted with a suitable solvent. For different analytical methods, further processing steps like SPE or solvent exchange to deuterated solvents for NMR are needed. After measurement, different data processing steps are needed to yield a suitable data matrix for downstream analysis. 

Most deuterated solvents for NMR spectra were purchased from Merck, Sharp, and Dohme, and all were 99+ atom% D. 

Choice of Solvent. The most appropriate solvent for NMR studies of polymers would allow a range of polymer concentrations to be investigated, be free of overlap problems and hopefully provide a signal for internal lock. Not all of these conditions can usually be met as many high molecular weight polymers pose solubility problems and can be examined in only a limited number of solvents. Deuterium resonance is the typical choice for an internal lock signal on most modern NMR spectrometers. Unfortunately, the majority of available deuterated solvents are poor solvents for many addition polymers such as the polyolefins while it is generally possible to find a number of appropriate deuterated solvents for many of the condensation polymers. The... 

Liquid S02 is a useful non-aqueous solvent.51 Although it is a relatively poor ionizing medium (e= 15.1 at 0°) it dissolves many organic and inorganic substances and is often used as a solvent for nmr studies as well as in preparative reactions. There is little evidence for self-ionization of liquid S02, and the conductivity (3xl0-8 to 2 x 10-7 ohm cm-1) is mainly a reflection of the purity. 

Early in our investigation of 1, acetonitrile was used as a solvent for NMR studies. Surprisingly, this solvent reacted with 1 to form a trans-hydrido cyanomethyl complex of the type ... 

D2O can be used as a solvent for NMR when it is difficult to dissolve polar compounds in the standard solvents. For instance, many acids are difficult to dissolve in CDCI3. A basic solution of... 

If we use a chiral solvent for NMR spectroscopy, then chemical shifts induced by solute-solvent interactions may be different for enantiotopic protons, and the spectrum may show differences between them. Moreover, chiral shift reagents can also make them distinguishable. ... 

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