Solvent evaporation method nanoparticle fabrication

In a study, polymeric nanoparticles (NPs) composed of a new redox-responsive polymer, poly(ethylene glycol]-b-poly(lactic acid] [MPEG-SS-PLA], were prepared to carry paclitaxel [PTX] for glutathione (GSH]-regulated drug delivery. The PTX-loaded MPEG-SS-PLA NPs were fabricated using an optimized oil-in-water emulsion/solvent evaporation method. The HPLC results revealed that the NPs released almost 90% PTX within 96 h when GSH presented at intracellular concentrations, whereas only a very small PTX amount was released at plasma GSH levels. The MTT assay results show that the NPs caused concentration- and time-... 

Nanoparticle fabrication includes methods such as solvent evaporation, spontaneous emulsification, solvent diffusion, salting out/emulsification diffusion, and polymerization techniques [24]. The synthesis method can greatly impact the particle s physical, chemical, and biological properties and the dispersion and stability of the particles, which are important considerations in biomedical applications. The nanoparticle size and shape is of great importance because the internalization, circulation, distribution, and targeting aspects of the system can be affected by these characteristics [5]. 

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