Solvent Effects on Molecular Recognition

It is widely recognized that binding processes are dependent upon the solvent used. For example, the enthalpy and entropy changes in complex formation between (— )-63 and L-valine methyl ester were -21.3 kJ/mol and -f 10.5 J/K/ mol at 293 K, respectively, in CHCl containing 0.5% ethanol as a stabilizer they were —125.5 kJ/mol and 

As another example, the value of binding free energy, 

Entry Host Guest -AC°/kjTTiol Solvent Temperature (K) Method Reference 

Entry Host Guest -AH /k -mol -AS /)-K -mol Solvent Method Reference 

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We now consider the solvent effect on molecular recognition. Let L be a relatively small ligand and P a large polymer. We assume that L can bind to several distinguishable sites of P. For each site /, the association reaction is... 

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