Solution- versus solid-phase chemistry

Solid-supported chemistry is very useful for the synthesis of larger series of compounds investments in the development of methods will be paid off by faster production through simple robotic methods. 

Compound mixtures versus single compound collections 

As pointed out earlier, combinatorial and parallel synthesis are used to synthesise mixtures as well as single compounds. When evaluating the advantages and drawbacks of mixtures and single compound collections it is important to consider the following aspects  

Type of library random libraries large compound libraries consisting of highly diverse compounds mixtures and single compounds) 

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The advantage of solution phase approaches for constructing combinatorial libraries is the direct translation of known solution chemistry to library synthesis, versus the need to reengineer these chemistries to be compatible with the solid phase environment. Three approaches have been reported for generating solution phase oligosaccharide libraries [27-30]. The first reported strategy attempted to address one of the inherent challenges and costs associated with... 

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