Solution structure of proteins and nucleic acids

In diamagnetic proteins the most useful spectral features that can be correlated with the characteristics of the three-dimensional structure are  

Limited direct comparisons of crystal and solution structures of macromolecules can be made, based on the fact that the high-resolution NMR spectrum can be regarded as a fingerprint of the total structure [95]. Since recently it has become 

Similarity of substrate and inhibitor binding sites of enzymes in the crystal and in solution can often be demonstrated by a comparison of NMR and X-ray data, and 

---