Solution stability, somatotropins

There is an extensive literature that discusses the stabilization of proteins in solution and for processing as a consequence of pH, temperature, and solutes (see, e.g., Lee and TimashelT, 1981 Carpenter era/., 1986). The conditions that stabilize a given protein are usually unique to that particular protein. Following the development of large-scale production of somatotropins by recombinant technology, there was considerable development activity on the stabilization of the somatotropins, as revealed in the patent and journal literature. 

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