Solubilization of antibiotics

The soluble Kollidon products form reversible complexes with many hydrophobic active substances, and clear solutions in water are thus obtained. This may be affected by the molecular weight. The longer the chains or the higher the -value of the Kollidon type are, the stronger the solubility effect is, and thus the greater the solubility that can be obtained by the active substance. In practice, this effect was mostly exploited for the solubilization of antibiotics in human and veterinary medicine. There are also restrictions on the use of this substance in human parenter-als. In many countries the -value must not exceed 18, and there is also a restriction on the amount to be used for each dose administered in intramuscular application. 

Mrestani, Y., Marestani, Z., and Neubert, R. 2001, Characterization of micellar solubilization of antibiotics using micellar electrokinetic chromatography. J. Pharm. Biomed. Anal. 26, 883. 

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See also in sourсe #XX -- [ ]

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