Solid supported organic

During the past 20 years, solid-supported organic catalysts have become powerful synthetic tools readily available to the chemical community. The reasons for developing an immobihzed version of a chiral catalyst go weU beyond the simple-yet still fundamental-aspect of the recovery and recycling of the precious catalytic species. Catalyst stabihty, structural characterization, catalytic behavior, new or different solubihty properties, simphfication of the reaction work-up, catalyst discovery and optimization, use in environmentally friendly or green solvents are all issues that may be converhently addressed working with supported systems. 

Microreactors containing a solid-supported organic catalyst have also been developed. For example, solid-supported l,5,7-triazabicyclo-[4.4.0] undec-3-ene is introduced to a microtube reactor (Figure 7.26).This packed-bed microreactor has been used for Knoevenagel condensation... 

Those people who have tried here to summarise solid-supported organic synthesis in a hopefully clear and comprehensive way agree ... 

Solid-supported organic chemistry has only just started to become a new dimension in organic synthesis"... 

Historical landmarks in solid-supported organic synthesis... 

J. A. Bristol, Ed., Applications of Solid-Supported Organic Synthesis in Combinatorial Chemistry. Pergamon Press, Oxford, 1997. 

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