Solid-phase linkers Rink ester linker

It should be noted that the success of soHd phase Suzuki reactions can be dependant on the linker. In a study by Fernandez et al., optimal conditions for the Suzuki coupling of solid-supported 5-bromonicotinic acid with various boronic acids were found to vary for three different resins [126]. For amide resins, i.e.. Rink and BAL, aqueous base in a toluene/EtOH solvent gave high yields and purities for a range of boronic acids. However, for ester-bound Wang resin, anhydrous conditions were required to achieve good conversion over a wide variation in the aryl boronic acid. 

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