Solid oral dosage form Controlled release tablets

Special solid oral dosage forms are the controlled-release tablets. In some cases, it is desirable that the release of the drug from the tablet should be more gradual than in the normal case. This controlled slow release can be achieved in different ways. 

This technique could be extremely important for assessing the controlled-release properties of a solid oral dosage form. The homogeneity and quality of the manufacturing process could be determined. Also, this technique could be applied to the analysis of the surface of beads, tablets, and granulations, allowing the chemical composition of more than one layer to be evaluated. 

I Advantages. Carbamazepine was approved as an AED in 1974 and has been well studied. Oral immediate- and extended-release solid and liquid dosage forms are available. The oral solid dosage form is available as an immediate-release tablet and as a sustained-release capsule and a controlled-release tablet. The sustained- and controlled-release dosage forms allow for twice-daily dosing to reduce the... 

Breaking points are the availability of the raw materials and primary containers of reliable suppliers, the feasibility of analysis of the drug substance and the preparation and the availability of equipment. As an example, preparation processes such as tableting, freeze-drying or aseptic production are accessible in a few pharmacies. The preparation of oral solids with controlled release is not possible in pharmacies mainly to lacking equipment (fluidised-bed techniques and instrumental analysis, etc). Working with radiopharmaceuticals also requires very specific facilities, as is the case with preparation of solid dosage forms with hazardous substances. 

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