Solid dosage forms acetaminophen

M. Tomassetti, A. Catalan , V. Rossi, and S. Vecchio, Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms in some binary mixtures, J. Pharm. Biochem. Anal. 37 (2005), 949-955. 

Standard adult dosage of acetaminophen is identified as 325 mg. Children s standard dosage is 80 mg or 160 mg. Standard dosage means the amount of acetaminophen in a tablet or other solid dosage form. The amount of the drug can be increased to 500 mg per tablet or capsule if it is stated on the label that it is not the standard adult dosage form. Liquid forms of acetaminophen intended for adult use shall contain one adult standard dosage form per teaspoon. 

Fatmi, A.A. Williams, G.V Simultaneous determination of acetaminophen and hydrocodone bitartrate in solid dosage forms by HPLC. J.Liq.Chromatogr., 1987,10, 2461-2472 [simultaneoushydrocodone formulations]... 

Ting, S. Liquid chromatographic determination of levodopa, levodopa-carbidopa, and related impurities in solid dosage forms. J.Assoc.Off.Anal.Chem., 1986, 69, 169-173 [simultaneous carbidopa, levodopa acetaminophen is IS formulations]... 

Alvi, S.U. Castro, F. A stability-indicating simultaneous analysis of acetaminophen and hydrocodone bitartrate in tablets formulation by HPLC. J.Liq.Chromatogr., 1987, 10, 3413-3426 [stability-indicating simultaneous impurities, acetaminophen, codeine, hydromorphone tablets column temp 30] Fatmi, A.A. Williams, G.V. Simultaneous determination of acetaminophen and hydrocodone bitartrate in solid dosage forms by HPLC. J.Liq.Chromatogr., 1987, 10, 2461—2472... 

Finally, a series of papers have been published on the solid state NMR spectra of a number of analgesic drugs. Jagannathan recorded the solid state 13C NMR spectrum of acetaminophen in bulk and dosage forms [60], From the solution-phase NMR spectrum, assignments of the solid state NMR resonances could be made in addition to explanations for the doublet structure of some resonances (dipolar coupling). Spectra of the dosage product from two sources indicated... 

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