Solanum laciniatum

Solasodine Solanum dulcamara Solanum nigrum Solanum laciniatum... 

Use Solasodine and tomatidenol are used in the commercial synthesis of hormonally active steroids. Solasodine is obtained on an industrial scale from Solanum laciniatum (e. g.. New Zealand, Australia, Mexico, the former USSR), S. marginatum (Ecuador), and S. kha-sianum (India) For toxicity and pharmacological activity of some compounds, see Ut. and Solanum steroid kaloid glycosides. 

Solasodine, the glycoalkaloid used in production of contraceptives, is obtained from the Australian species Solanum laciniatum and S. aviculare, which are now cultivated in several countries for this purpose (Bradley et al. 1978). 

CiONGA, E., E. Nichtforesco, V. Mascov, N. Uricartj et S. Arizan Consideration sur rhydrolyse des glucoalcaloides du Solanum laciniatum AIT. Ann. Pharm. Fran9. 25, 139 (1967). 

A comprehensive survey of the solasodine content of 85 native Australian Solanum species has been published. Several studies have appeared which describe the changes in distribution and concentration of solasodine during the Ufe cycle of S. laciniatum. The effects of light colour on the solasodine content of 5. laciniatum and on the solasodine content of clones of 5. dulcamara have been studied the effect of ecological factors on alkaloid production by these two species has also been investigated. The solasodine contents of developing berries,fruits, and seed callus of S. khasianum have been reported. 

Solasodine see a-Solasonine. a-Solasonine, solasonine a Solanum steroid alkaloid occurring in many species of Solanum, e.g. S. sodomeum, S. aviculare, S. laciniatum and X nigrum. It is a glycoalkaloid containing the aglycon, salaso-dine [(22R 25R)-spirosol-5-ene-3p-ol], M, 413.67, m.p. 201 °C, [aJo -107° (CHCI3) and a branched trisaccharide. 

The biosynthesis of spirosolane alkaloids in tissue cultures of Solanum spedes has been reported 317-320, 375-377, cf. 321-325). Still, other authors were able to find only diosgenin and not any solasodine (1) in tissue cultures of S. laciniatum 326 cf. 316). The presence and content of spirostanols and/or spirosolanols may be dq)endent on the ratio of plant growth substances, e.g., 2,4-D, kinetin, and gibberellic add 318). It is reported that the addition of cholesterol increases the solasodine content 320). 

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