Soft cube model

The soft docking model represents the target and docking molecules as a collection of cubes rather than spheres. This method combines aspects of surface complementarity, grid search, and soft potential modeling. The cubic representation along with a grid search makes the translational and rotational searches much more efficient. In addition, the cubes implicitly allow for some volume overlap, which can be used in combination with surface complementarity to screen docked complexes [208]. 

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