Sodium-glucose transporter type

SODIUM-GLUCOSE TRANSPORTER TYPE 2 (SGLT2) INHIBITORS... 

SODIUM-GLUCOSE TRANSPORTER TYPE 2 (SGLT2) INHIBITORS [SEDA>33, 898 SEDA>34, 695] ... 

Scheen AJ (2015) Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs 75 33-59 Scheen AJ (2015) SGLT2 inhibition efficacy and safety in type 2 diabetes treatment. Expert Opin Drug Saf 14 1879-1904... 

While the characteristics of this type of transport have been studied and identified in a number of cell systems and for a number of substances (Table 6), little is known of the molecular mechanism involved, although kinetic analysis of facilitated diffusion may be found (Stein, 1967 Neame and Richards, 1972). However, because the proposed mechanism involves a reversible reaction of the substrate with a membrane carrier to form a complex which traverses the membrane and releases the substrate at the other side, it may be that facilitated diffusion mechanisms do not differ from those involved in active transport of the same molecule (Csaky, 1965 Wilbrandt, 1972). Specifically, the active transport of D-glucose may simply require the presence and cotransport of sodium ions (Crane, 1962 Stein, 1967). This theory has recently received support from studies of Na+-gradient-dependent uptake of o-glucose by isolated intestinal and renal brush border membranes (Murer and Hopfer, 1974 Kinne et al., 1975). However, the elec-trogenic nature of D-glucose transport is probably more accurately class-... 

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