Sodium fonnate, reaction with

The diethyl 2-(ethoxycarbonyl)ethylphosphonate is prepared in 35% yield from sodium diethyl phosphite and ethyl 3-iodopropionate. -- Similarly, methyl 2,3-dibromopropionate reacts with sodium diethyl phosphite with fonnation of diethyl 2-(methoxycarbonyl)ethylphosphonate in low yield (15%). ° Most likely, these reactions occur via an elimination-addition process promoted by the sodium diethyl phosphite. Treatment of ethyl 3-bromobutyrate with sodium dibutyl phosphite in toluene at VO C affords dibutyl l-methyl-2-(ethoxycarbonyl)ethylphosphonate in 62% yield, ... 

The reaction lesembles the fonnation of methane from sodium acetate when heated with soda-lime. 

Amine 39, prepared by catalytic reduction, is separated from the catalyst by filtration through Cclite, and the resulting methanolic solution is treated with sodium methoxide. Under these basic conditions the mesylate is replaced by an amine in an SN2 reaction and the lactone is also opened with fonnation of the thermodynamically more stable lactam 11. 

Potassium and sodium salts of primar> - nitraniines react with compounds containing active chlorine, for example picryl-A -cliloride and potassium methyl-nitramine yielded tetryl [35]. An interesting application of this reaction is the fonnation of a polymer from disodium salts of dinitramines and bis-A -cliloro-methylnitramir.es [36j ... 

The reaction of NjO with NaNH in liquid ammonia is a somewhat complicated reaction. At first the reaction forms a complex 2 NaNllj, NjO. In the presence of an excess of ammonia over 0 C sodium azide is formed. However in the presence of sodium hydroxide the basic sodium azide (NaN3.2NaOH) results. A higher temperature (e.g. 30—50 C) favours the formation of the basic compound, whale a temperature of ca. 0 C prevents the fonnation of this substance. 

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