SnRNPs small nuclear

Splicing occurs in a large protein-nucleic acid complex, termed the spUceosome. Components of the spliceosome are, apart from the pre-mRNA, a number of proteins and small RNAs, termed the Ul, U2, U4, U5 and U6. The RNAs found in the spUceo-some are bound to specific proteins. The complexes are termed snRNPs (small nuclear ribonucleoprotein). Depending upon the type of RNA bound, there are Ul, U2, U5 and U4/U6 snRNPs. 

Removal of introns. snRNP = small nuclear ribonucleoprotein particle. 

NADH nicotinamide adenine dinucleotide snRNP small nuclear ribonucleoprotein... 

To assist in the modification and processing of mRNAs, eukaryotic cells contain in their nuclei small nuclear RNAs (snRNAs), which are complexed with specific proteins to form small nuclear ribonucleoprotein particles (snRNPs). These RNAs have been named U1, U2, U3,.. . , U13 and range in size from 100 to 220 bases. One, U3, is... 

The small nuclear ribonucleoprotein particles (snRNPs or snurps ) that carry out the splicing reaction use RNA-RNA basepairing to select the splice sites. Almost all intron-exon junctions contain the sequence AG-GU with the GU beginning the intron sequence. Furthermore, the consensus sequence for the beginning of the intron has a longer sequence complementary to the U1 RNA. Thus, assembly of the splicing complex, called the spliceosome, starts when the RNA component of the U1 snRNP base pairs with the junction between the 3 end of the exon and the 5 end of the intron. See Figure 12-13. 

Table 11.4 Small Nuclear Ribonucleoprotein Particles (snRNP) in Splicing of mRNA Precursors...

D, Keller W. Functions of the abundant U-snRNPs. In Small Nuclear Ribonucleoprotein Particles. Birnstiel ML, ed. 1988. Springer-Verlag, Berlin. 53. 

Table 28.3. Small nuclear ribonucleoprotein particles (snRNPs) in the splicing of mRNA precursors...

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