Smoked administration route marijuana

Information on the mutagenic potential of SNA Is almost completely lacking. A single abstract reported the cytogenetic effect of chronic use of the drug over 2-3 yr by one male and four females 18-26 yr old. The most frequent route of administration was Inhalation of smoke from a blend of SNA and marijuana. No chromosomal abnormalities were found In this limited investigation. 8... 

The human data, as well as the animal studies indicate that cannabinoids may ameliorate some symptoms of MS. Unfortunately, a definitive large-scale study has yet to be performed. Such a study should take into account that (a) the placebo effect in MS is very high (b) the effective doses recorded are close to, or identical with the doses that cause cannabimimetic effects (c) cannabis (marijuana, hashish) is obviously not identical to zf9-THC, and that other constituents may synergize THC action (d) smoking cannot be compared with oral administration, and (e) the anal route of administration [141] may be a preferred one. 

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