Small Molecules to Promote Dedifferentiation and Transdifferentiation

The most fruitful approach to the identification of small molecules to reprogramme cell fate has been through the screening of combinatorial libraries. In 2002, Schultz and co-workers, identified the purine myoseverin in a screen designed to identify small molecules capable of dedifferentiating 

Thought to alter myotube morphology rather than true dedifferentiation 

Enhances iPS cell generation from NPCs transduced with Oct 314 and Klf4 

Compound Structure Role Possible target Notes Reference 

H x N 0 X) Neuronal trans-1 differentiation 1 from skeletal Cl muscle cells — — Williams et al  

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