SMID, Small-molecule interaction database

Another way to predict protein-SM interactions is to assume that similar protein sequences bind similar SMs. This is a simple, yet powerful assumption, providing accurate interaction predictions, demonstrated in a number of studies. The actual implementation of this idea into a computational algorithm is limited only by human imagination and available time, so its discussion is beyond the scope of this chapter. One interesting sequence-based interaction prediction approach reported by Synder and co-workers [61] was used to create the small-molecule interaction database (SMID) (Fig. 2-12). Biologically relevant SMs were determined from three-dimensional x-ray crystal structures containing... 

Blueprint s Small-Molecule Interaction Database (SMID), 2006 http //smid.blueprint.org. 

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