Small annotation

The described applications rely heavily on the available information sources, which usually means small-molecule databases annotated with bioactivity data. Due to the... 

Figure 1 Comparison of the CGRP family peptides. The amino acids are annotated in the following way small and hydrophobic in plain text, acidic in bold, basic in bold italics and hydroxyl or amine in italics. Indicates identical or conserved residues in all peptides indicates conserved substitutions and indicates semi-conserved substitutions.

Fontsize specifications Plot annotating utilities such as xlabel, ylabel, text, and title allow fontsize settings for displayed text such as xlabel (.. . , FontSize , 12). Here 12 indicates the font to be used. Fontsize 14 is rather large and fontsize 8 rather small. 

You can see from Table 8.1 that 98% of the reflections available out to 2.7 A [those lying within a sphere of radius 1/(2.7 A) centered at the origin of the reciprocal lattice] were measured, and on the average, each reflection was measured four times. Additional reflections were measured out to 2.4 A. The number of available reflections increases with the third power of the radius of the sampled region in the reciprocal lattice (because the volume of a sphere of radius r is proportional to r3), so a seemingly small increase in resolution from 2.7 to 2.4 A requires 40% more data. [Compare (1/2.4)3 with (1/2.7)3.] For a rough calculation of the number of available reflections at specified resolution, see annotations of the 4/92 paper. 

SwissProt is a relatively small but highly annotated database with minimal redundancy. NCBInr and MSDB are much larger, but have multiple entries for many proteins. Other search engines may have additional database choices, and in-house copies allow custom databases to be used. 

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