Slow channel transport mechanical activity

The dependence of the transport activity on the mole fraction of a binary mixture of fast and slow ions is a classical test for a cooperative multi-ion transport mechanism. Commonly, a negative deviation from a simple linear additivity is considered an anomalous mole fraction effect (AMFE) and confirms the existence of multiple ion binding sites along the conduction pathway (Figure I4a). i The conventional explanation refers to the presumption of single-file ion channels, in which occupation of more than one binding site is necessary for the ions to move really fast (Figure 14c and d). However, this... 

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