Sleep disordered breathing prevalence

In addition to the sleep disturbances that result from normal aging or brain disease, sleep quality may be impaired by primary sleep disorders, some of which occur with increasing prevalence with age. Sleep disordered breathing (sleep apnea), restless legs syndrome (RLS) and REM sleep behavior disorder (RBD) are three such primary sleep disorders that are more prevalent in older adults. 

Bixler EO, Vgontzas AN, Lin H-M, Have TT, Rein J, Vela-Bueno A, Kales A (2001) Prevalence of sleep-disordered breathing in women. Effect of gender. Am J Respir Crit Care Med 163 608-613... 

OHS, previously called the Pickwickian syndrome (6), is defined as the association of obesity, sleep-disordered breathing (SDB) with daytime h)q)ersomnolence, and hypercapnia (Pacc>2 > 45 mmHg) in the absence of any other respiratory disease (Fig. 1). SDB can present as obstructive apneas and hypopneas, obstructive hypoventilation due to increased upper airway resistance, and/or central hypoventilation (7). The prevalence of OHS is 36% in patients with BMI between 35 and 40 kg/m, and 48%, if BMI equals or exceeds 50 (8). Without adequate treatment, patients with OHS develop cor pulmonale and recurrent episodes of hypercapnic respiratory failure, and loss of survival (Fig. 2). OHS is one of the many etiologies of CRF and has become a growing indication to initiate longterm noninvasive ventilation (NIV) in most European countries (9,10). 

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