Skin disorders acne vulgaris

The past twenty years have witnessed considerable progress in the synthesis and use of other retinoid-like molecules related to vitamin A. The aromatic retinoid etretin (8.54) and its ester etretinate (8.55) had some effectiveness in the treatment of psoriasis, a disorder of skin. 13-cA-Retinoic acid (isotretinoin) produces sebaceous gland atrophy and could prove useful in the treatment of severe acne vulgaris. Although these compounds have toxic side effects and are not in regular use, they have opened up new therapeutic possibilities. Retinoic acid (tretinoin, 8.56) has been employed in the treatment of acne. 

In the United States, acne vulgaris is the most common skin disorder, affecting 40 to 50 million people. 

In the United States, acne vulgaris is the most common skin disorder, affecting between 40 and 50 million people. Acne vulgaris affects approximately 80% of the population between the age of 12 and 25 years, with no gender, race, or ethnicity prevalence. ... 

Acne vulgaris is the most common dermatologic disorder treated with either topical or systemic antibiotics. The anaerobe P. acnes is a component of normal skin flora that proliferates in the obstructed, lipid-rich lumen of the pdosebaceous unit, where tension is low. P. acnes generates free fatty acids that are irritants and may lead to microcomedo formation and result in the inflammatory lesions of acne. Suppression of cutaneous P. acnes with antibiotic therapy is correlated with clinical improvement. 

The skin is the site of several common disorders that include acne vulgaris, psoriasis, eczema dermatitis, contact dermatitis, drug-induced dermatitis, and bums. Some disorders result from viral infections such as herpes simplex and herpes zoster. Some result from fungal infections such as tinea pedis (athlete s foot) and tinea capitis (ringworm). 

There are many skin disorders. The more common are acne vulgaris, psoriasis, warts, dermatitis, alopecia, bums, abrasions, and lacerations. 

Zinc oxide occurs in nature as the mineral zincite, and can be prepared from zinc metal by vaporization and oxidation. It can also be prepared from franklinite or zinc sulfide. It is a very fine, odorless, amorphous, white or yellowish white powder. Zinc oxide has a mild astringent, protective and antiseptic action, and is usually formulated into ointment, paste or lotion vehicles. It is used widely in the treatment of dry skin and disorders such as acne vulgaris, prickly heat, insect bites, ivy poisioning, diaper rash, seborreha, impetigo, and psoriasis. It is also contained in some simscreens. 

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