Skelton Group

Granite Harbor Intrusives Ross Supergroup Koetthtz and Skelton groups... 

Adams CJ, Whitla PF (1991) Precambrian ancestry of the Asgard Formation (Skelton Group) Rb-Sr age of basement metamorphic rocks in the Dry Valley region, Anteirctica. In Thomson MRA, Crame JA, Thomson JW (eds) Geological evolution of Antarctica. Cambridge University Press, Cambridge, pp 129-135... 

Skinner DNB (1982) Stratigraphy and structure of low-grade metasedimentary rocks of the Skelton Group, southern Victoria Land Does the Teall graywacke really exist In Craddock C (ed) Antarctic geoscience. University of Wisconsin Press, Madison, WI, pp 555-563... 

This modification resulted in a yield improvement for the pentacyclization process from 47 % to 66 %. Treatment of the amino ether 192 with diisobutylaluminum hydride in refluxing toluene accomplished Eschenmoser-Grob fragmentation and reduction of the initially formed immonium ion, to give the unsaturated amino alcohol 193 in 86% yield. It was gratifying to find that 193 was the only product formed in this reaction. In the tetrahydropyran derivative, reduction of 192 to 193 is accompanied by about 15 % simple elimination. Displacement of the tosyl group in 196 gives sulfide 197, which is oxidized to sulfone 198. This material is metallated and coupled with enantiomerically pure aldehyde to secure the codaphniphylline skelton [74]. 

Optically active aldehydes are desirable synthetic precursors for the construction of chiral carbon skeltones in organic synthesis. Several methods had been devised for the synthesis of optically active aldehydes employing chiral enamines chiral imines or chiral hydrazone however, little was known about the asymmetric synthesis of chiral aldehyde having a functional group in the same molecule... 

The structure-insecticidal activity relationships of picrotoxinin analogs and related compounds have been studied by several researchers (3,16), who noted that the bridged bicyclic lactone skelton and the trans-isopropenyl or isopropyl group are essential for insecticidal activity. Structure-activity relationships of cyclodiene insecticides and BHC have also been thoroughly discussed (17-19). However, these discussions were published before the nature of the biological target site(s) for cyclodienes was known. 

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