Site selective couphng reactions

Alternative methods of highly selective coupHng reactions were developed using enzymes. These methods were easier to develop on a large number of proteins with little effort. In the first example, the PEG chain can be transferred on an O-glycosylated site of glycosylated native proteins. The reaction can be catalysed by a specific enzyme, a glycosyl transferase, which confers a... 

Sanford [217] demonstrated a controlled site selectivity in an oxidative coupling. When palladium complex 153a (X = OAc) was used in the presence of AcOH as additive, the couphng reaction with an arene occurred at its meta position to... 

---