Sirtuin family regulator

SIRTl belongs to the mammalian sirtuin family of NAD -dependent histone deacetylases (HDAGs) [198, 199]. Targets known to be deacetylated by SIRTl include histone 4 (H4), NFkB, and p53 [198, 199]. Through its deacetylase activity, SIRTl is considered to control cellular metabolic homeostasis, and to play important roles in the regulation of gene expression, cell proliferation, differentiation, survival, and senescence [198, 199]. SERTl activation has been considered to play a crucial role in calorie-restriction-induced longevity in several species [200]. 

Sirtuins represent a novel family of enzymes that are collectively well situated to help regulate nutrient sensing and utilization, metabolic rate, and ultimately metabolic disease. It was shown that resveratrol activated one of these enzymes, SIRTl [32]. The adivation of SIRTl leads to enhanced activity of multiple proteins, including peroxisomeprohferator-activated receptor coactivator-la (PGC-la), which helps mediate some of the in dtro and in invo effects of sirtuins. Resveratrol, given in a proprietary formulation SRT-501 (3 or 5 g), reached 5-8 times higher blood levels. 

---