Siphonaria pectinata

Biogenetic considerations [71], and a correlation of all polypropionates from pulmonate molluscs led to revision of the relative stereochemistry of pectinatone (20) and nor-pectinatone (21), metabolites of the pulmonate Siphonaria pectinata [72, 73] the point had already been questioned by Oppolzer s synthesis [74] and was definitively confirmed by two independent X-ray diffraction studies [71, 75] of pectinatone (20). 

Active-Site Nucleophile of Bacillus circulans Xylanase Novel Metabolites of Siphonaria pectinata... 

Diemenensin-A (882) inhibited Staphylococcus aureus and Bacillus subtilis at 1 pg/disc and 5 pg/disc, respectively, and inhibited cell division in the fertilized sea urchin egg assay at 1 pg/mL. Another new polypropionate antibiotic with a y-hydroxy-a-pyrone ring, pec-tinatone (884) was isolated from Siphonaria pectinata (592). S. denticu-lata furnished two isomeric polypropionate metabolites, denticulatin A (885) and B (886) (593). Denticulatin A (885) was ichthyotoxic at 10 pg/mL while 886 was reported to be toxic at 30 pg/mL. Norpectina-tone (887) and the E- and Z-isomers 888 and 889 of a related furanone were constituents of the Chilean pulmonate S. lessoni (594), and a cyclic hemiacetal (890) as well as an associated ketol ester (891) were reported as metabolites of S. australis (595). Hochlowski et al. (596) investigated four other Siphonaria species and isolated siphonarin-A (892)... 

Biskupiak, J.E., and C.M. Ireland Pectinatone, a New Antibiotic from the Mollusc Siphonaria pectinata. Tetrahedron Lett. 24, 3055 (1983). 

Siphonaria pectinata Biskupiak and Ireland, 1983 Garson etaf 1990... 

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