Siphonaria australis

Sundram, U.N. and Albizati, K.F. (1992) Synthesis and absolute configuration of polypropionate metabolites of Siphonaria australis. Tetrahedron Lett., 33, 437—440. 

Siphonaria australis Hochlowski and Faulkner, 1984 Sundram and Albizati, 1992... 

Diemenensin-A (882) inhibited Staphylococcus aureus and Bacillus subtilis at 1 pg/disc and 5 pg/disc, respectively, and inhibited cell division in the fertilized sea urchin egg assay at 1 pg/mL. Another new polypropionate antibiotic with a y-hydroxy-a-pyrone ring, pec-tinatone (884) was isolated from Siphonaria pectinata (592). S. denticu-lata furnished two isomeric polypropionate metabolites, denticulatin A (885) and B (886) (593). Denticulatin A (885) was ichthyotoxic at 10 pg/mL while 886 was reported to be toxic at 30 pg/mL. Norpectina-tone (887) and the E- and Z-isomers 888 and 889 of a related furanone were constituents of the Chilean pulmonate S. lessoni (594), and a cyclic hemiacetal (890) as well as an associated ketol ester (891) were reported as metabolites of S. australis (595). Hochlowski et al. (596) investigated four other Siphonaria species and isolated siphonarin-A (892)... 

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