Single template structure

During the rephcation of DNA, there must be a separation of the two strands to allow each to serve as a template by hydrogen bonding its nucleotide bases to the incoming deoxynucleoside triphosphate. The separation of the DNA double hehx is promoted by SSBs, specific protein molecules that stabihze the single-stranded structure as the rephcation fork progresses. These stabi-... 

This conformation resembles that determined by X-ray single-crystal structure analysis. Apart from a close interaction of the -system of the amide groups with the para-substituted aryl moieties, no further n-n interactions are observed. The template-assisted catenane formation is on this account mainly driven by hydrogen-bonding, and n-n interactions are of minor importance only. 

Marine Sterols. Several hundred unique sterol structures have been elucidated from a variety of marine invertebrates. A single nucleus can be used to describe most terrestrial sterols, but no single template suffices for marine sterols, Similar to cholesterol, marine sterols play a critical role in both the physiology and biochemistry of biological systems. 

The simplest type of rigid-body method involves simply transferring the backbone conformation of the core of the protein from a single template to the unknown protein. An alternative is to construct a framework by averaging the structures from a number of protein templates Each template can be given a weight related to its sequence similarity to the unknown target [Srinivasan et al 1996]... 

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