Single Occupancy Cell Method

Let us consider the main ideas of these methods on an example of a structureless lattice gas of monolayer adsorbate. The distribution of adatoms over discrete cells can be described by a many-particle distribution function F n,t) (n = (ni,Ti2. .. n, ), k = Nc), where rij is the occupation number of a cell number j uj = 0,1 for single-place cells), Nc - the total number of ceils that is considered to be a constant (we neglect here the processes of surface reconstruction). The distribution function F(n, t) is normalized by the condition... 

The current immunofluorescence method is limited to the detection of adduct levels around 1/10 nucleotides. Coaq>uter-assisted video microscopy systems or the use of biotin-streptavidin staining should further increase sensitivity. It may then be possible to utilize these methods for adduct detection in human samples from occupational or environmental exposures. Since adducts can in theory be visualized in single cells, the small amount of material obtained at biopsy could be utilized. 

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