Single molecule force

Rief, M., Oeslerhelt, F., Heymann, B. and Gaub, H.E., Single molecule force spectroscopy on polysaccharides by atomic force microscopy. Science, 275(5304), 1295-1297 (1997). 

Hummer, G. Szabo, A., Free energy surfaces from single-molecule force spectroscopy, Acc. Chem. Res. 2005, 38, 504—513... 

Oroudjev, E., Soares, J., Arcdiacono, S., Thompson, J. B., Fossey, S. A., and Hansma, H. G. (2002). Segmented nanofibres of spider dragline silk Atomic force microscopy and single-molecule force spectroscopy. Proc. Natl. Acad. Sci. USA 99, 6460-6465. 

Noncovalent Cross-Linking of Casein by Epigallocatechin Collate Characterized by Single Molecule Force Microscopy (from Jobstl et al., 2006)... 

Jobstl, E. Howse, J. R. Fairclough, J. P. A. Williamson, M. P. Noncovalent Cross-Linking of Casein by Epigallocatechin Gallate Characterized by Single Molecule Force Microscopy. J. Agric. Food Chem. 2006, 34, 4077-4081. 

Gu C, Ray C, Guo S, Akhremitchev BB. Single-molecule force spectroscopy measurements of interactions between C60 fullerene molecules. J Phys Chem C 2007 111 12898-12905. 

Kersey FR, Yount WC, Craig SL. Single-molecule force spectroscopy of bimolecular reactions system homology in the mechanical activation of ligand substitution reactions. J Am Chem Soc 2006 128 3886-3887. 

Kudera M, Eschbaumer C, Gaub HE, Schubert US. Analysis of metallo-supiamolecular systems using single-molecule force spectroscopy. Adv Eunct Mater 2003 13 615-620. 

Schonherr H, Beulen MWJ, Bugler J, Huskens J, van Veggel FCJM, Reinhoudt DN, Vancso GJ. Individual suptamolecular host-guest interactions studied by d3mamic single molecule force spectroscopy. J Am Chem Soc 2000 122 4963-4967. 

Figure 10.2 Single molecule force-extension curve of three different types of molecules (a) a short chain or rigid tod molecule (b) a long chain polymer with multiple domains, such as titin, where bi-b represents the unfolding of individual domains and (c) a tegular random coil long chain. Adapted from Smith et al. (1999). Copyright 1999 Nature Publishing Group.

Fisher TE, Carrion-Vazquez M, Oberhauser AF, Li H, Marszalek PE, Fernandez JM. Single molecule force spectroscopy of modular proteins in the nervous system. Neuron 2000 27 435-446. 

Guzman DL, Roland JT, Keer H, Kong YP, Ritz T, Yee AF, Guan Z. Using computational single molecule force spectroscopy in rational design of strong, modular nanostructures for use in materials synthesis. Submitted 2007. 

Oroudjev E, Soares J, Arcdiacono S, Thompson JB, Fossey SA, Hansma HG. Segmented nanofibers of spider dragline silk atomic force microscopy and single-molecule force spectroscopy. Proc Natl Acad Sci USA 2002 99 6460-6465. 

Figure 10.6 (a) A molecular model for one double-closed loop (DCL) module used in the stody. (b) An AFM single molecule force-extension curve for the DCL modular... 

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