Single-Molecule Chemistry in Homogeneous Catalysis

Difficulties arise when turning to homogeneous reactions. Neither substrates nor catalysts sit still but diffuse freely in solution, making it impossible with current microscopy techniques to follow their fate for more than few milliseconds. Moreover, fast diffusion of the molecules significantly reduces the fluorescence intensity that can be detected in one pixel of a charge-coupled 

The trapping of smaller molecular entities in solution has so far not been reported. The difficulty in isolating individual catalyst is probably one reason why reports on single-molecule experiments with homogeneous (catalytic) reactions 

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