Single-domain optimum

Second-order model Optimum outside domain Single response OPTIMUM PATH... 

Based on the use of the Stoner-Wohlfarth theory for single-domain partieles, the Neel-Brown relaxation model, and equilibrium functions, Medahuoi et al. have composed a model that allows for a direct comparison of theoretical simulations and experimental results from hyperthermia experiments carried out in iron nanoparticles with particles sizes ranging from 5.5 to 28 nm." In the low field region, the optimum particle volume Vopi) can be calculated from the Neel-Brown model ... 

The analysis presented above for the effect of ceUobiose on CBH I thermal stability must be considered preliminary, in that equation 3, and therefore also equation 4, which is derived from equation 3, apply strictly only to single-transition processes. Equation 4 does, however, serve weU to illustrate the general type of peak-displacement being proposed here. Exact numerical appUcation of such an equation would require accurate estimates, not presently avaUable, for such quantities as the K. values for native CBH I and ceUobiose at pH values far remov from the activity optimum, and/or at temperatures at which the native enzyme, in the absence of the inhibitor, does not exist in measurable proportions. QuaUtatively, however, we beUeve that the analysis presented above can serve as a useful conceptual basis, or springboard, for further investigations of catalytic-domain structure and function. 

Screening and factor studies will sometimes indicate whether, and if so, where we should search for an optimum within the domain being studied. However, if the optimum (we are considering a single key variable here) lies outside the present experiment, then the steepest ascent method comes into its own. The direction... 

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