Single channel recordings

B Sackmann and E Neher, Single Channel Recording, Plenum, New York (1995). 

Figure 5. Scheme of the bilayer formation at the tip of the patch pipets (a) and single channel recordings of pardaxin pores (b). 

Conti, F., and E. Neher, Single channel recordings of K+ currents in squid axons, Nature, 285, 140 (1980). 

Sakmann, B., and E. Neher (Eds), Single-Channel Recordings, Plenum Press, New York, 1983. 

The ion-channel blocking mechanism has been widely tested and found to be important in both pharmacology and physiology. Examples are the block of nerve and cardiac sodium channels by local anesthetics, or block of NMDA receptor channels by Mg2+ and the anesthetic ketamine. The channel-block mechanism was first used quantitatively to describe block of the squid axon K+ current by tetraethylammonium (TEA) ions. The effects of channel blockers on synaptic potentials and synaptic currents were investigated, particularly at the neuromuscular junction, and the development of the single-channel recording technique allowed channel blockages to be observed directly for the first time. 

Dissected adult female the parasite has been cut longitudinally and the gut and reproductive organs removed to form the characteristic muscle flap . (C) Vesicles forming from a muscle cell after treatment with collagenase the vesicles are then transferred to the experimental chamber, where vesicle-attached patches are formed and single-channel recordings made. 

Stiihmer W, Parekh AB. 1995. Electrophysiological recordings from Xenopus oocytes. Single-channel recording. Second edition. Sakmann B, Neher E, editors. New York Plenum Press pp 341-356. 

Single-Channel Recording , Sakmann, B. Neher, E., Ed. Plenum Press NY, 1983. 

Gogelein H, Greger R (1984) Single channel recordings from ba-solateral and apical membranes of renal proximal tubules. Pfliigers Arch 401 424-426... 

Einhorn LC, Gregerson KA, Oxford GS (1991) D2 dopamine receptor activation of potassium channels in identified rat lactotrophs whole-cell and single-channel recording. J Neurosci 17 3727-3737. 

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