Simvastatin Tolbutamide

Cimetidine, fluconazole, fluvastatin, isoniazid, lovastatin, pravastatin, simvastatin, sulfaphenazole, tienilic acid, tolbutamide, warfarin... 

Metoprolol Midazolam Naproxen Nifedipine Omeprazole Ondansetron Orphenadrine Phenytoin Piroxicam Progesterone Propafenone Propranolol Quinidine Rifampin Sibutramine Sildenafil Simvastatin Tacrine Tamoxifen Terfenadine Testosterone Theophylline Timolol Tolbutamide Tramadol Triazolam Verapamil Warfarin (R) Warfarin (S) Zolmitriptan Zolpidem... 

A single 1-g oral dose of tolbutamide was given to two groups of 16 healthy subjects taking fluvastatin 40 mg or simvastatin 20 mg. The pharmacokinetics of the tolbutamide were affected only to a very minor extent, and the blood glucose-lowering effects of the tolbutamide were unchanged." ... 

There is little evidence to suggest that special precautions appear to be needed by diabetic patients taking any of the pairs of sulphonylureas and statins cited here (chlorpropamide with lovastatin, or glibenclamide or tolbutamide with fluvastatin or simvastatin). However, the manufacturers of fluvastatin suggest that a serious interaction cannot be ruled out and therefore advise that the use of glibenclamide should be avoided wherever possible. ... 

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