Simvastatin nephrotoxicity

It has been claimed that physicians should bear in mind the nephrotoxic potential of this drug (23), but there is no definite evidence that simvastatin is associated with the development of proteinuria (24). 

Johnson DW, Saunders FIJ, Field MJ, Pollock CA. In vitro effects of simvastatin on tubulointerstitial cells in a human model of cyclosporin nephrotoxicity. Am J Physiol 1999 276 F467-F475. 

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