Similarity Searching with Pharmacophore Fingerprints - Technical Issues

3 Similarity Searching with Pharmacophore Fingerprints - Technical Issues 

Prior to a brief discussion of specific applications of topological pharmacophore fingerprints in similarity-based virtual screening, some general remarks can be made. 

Similarity-driven retrieval of (hopefully) active analogs has nothing to do with actual pharmacophore elucidation. In a certain sense, it assumes that the query 

3 Similarity Metrics Should take Descriptor Nature into Account 

4 What can be Really Learned from Virtual Screening Simulations of Seeded Databases  

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