Similarity-based and Group Interchange Models

This transformation may be described as an interchange of the ethenyl and the oxiryl group while the remainder of the molecule, the /3-bromo-1 -phenyl-n-penty 1 group, remains intact. 

The GI approach relates the property, Yg, of a query compound to the known property, To, of a database compound, by the equation [36] 

Application of the GIM approach in property estimation requires the following steps  

Identification of appropriate database structures and their properties 

Recognition of the structural difference between the query and a selected candidate structure (i.e., assignment of LNGI) 

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