Similar Shape and Property Searches

The second group of approaches, seeking similarities in the shapes and chemical surface properties of binding sites, include recently developed tools such as CavBase [89, 90], eF-Site [91], and SuMo [92]. An earlier technique using surface shape only for binding site comparisons was reported by Rosen et al. [93], The reliability of this geometric surface-matching approach has been shown for the catalytic triad of serine proteases and chorismate mutase. 

Applications of Binding Site Analyses and Comparisons in Drug Design 

---