Silane, chloromethyltrimethyl

To a solution of trimethylsilylmethyl lithium (from chloromethyltrimethyl-silane (15.8mmoI) and lithium dispersion (196mmol)) in ether (30ml) was added cyclohexane carboxaldehyde (14.2 mmol) at ambient temperature, with stirring. After a further 10min at ambient temperature, the solution... 

Trifluoromethyl iodide is a poor substrate for SN2 reactions [28], The increased donativity of the methylene carbon as rendered by the fluorine atoms is reflected in its reluctance to enter a bonding relationship with a nucleophile. Similar reactivity patterns are known for chloromethyl phenyl sulfone [28] and chloromethyltrimethyl-silane. In these latter compounds the reactive center is directly linked to an acceptor group. 

Polyamines through alkylation reaction with chloromethylsilane 1 The secondary amine function of polyaza derivatives are alkylated using chloromethyltrimethyl-silane. 

Prepared by Finkelstein reaction from chloromethyltrimethyl silane and sodium iodide in acetone. 

If cyclopentadiene (154) is treated with sodium and then with chloromethyltrimethyl-silane (155), 2- and 3-TMS-methylcyclopentadiene (156,157) are formed (equation 74)99. 

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