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Sila-Pharmaca

Synthesis and biological investigation of organosilicon compounds, having analogous sila-substituted structures of organic compounds with well known bioactivity (- sila-pharmaca). [Pg.12]

Sila-pharmaca with a potential site of fracture in their framework could be useful in cases, in which the dmg shall act only for a short time (e.g. spasmolytic or analgesic compounds). After effecting in the desired manner the drug will be destroyed by the water of the biological surrounding without help of complex enzymatic systems. [Pg.45]

The syntheses of the sila-pharmaca were achieved through two different routes, as described in Scheme 17. [Pg.47]

In nearly all cases carbon atoms of organic drugs have at least one C-H bond. So it seems not to be very useful to substitute such carbon atoms for silicon atoms, because of the high hydrolytic sensitivity of Si—H bonds (Chap. 2). This fact reduces the possibilities of expanding the field of sila-pharmaca. [Pg.55]

Wannagat, U. Sila-pharmaca. In Biochemistry of silicon and related problems, pp. 447-471. New York Plenum Press, 1978... [Pg.74]

Wannagat, U. Sila-Pharmaca, (G. Bendz, I. Lindqvist, Eds.) Biochemistry of Silicon and Related Problems (Nobel Symposium), Plenum Press, New York, 1978. p. 447. [Pg.374]

We are paying great attention to the development of Sila-cosmetics , and Sila-pharmaca preparations are waiting their hour of triumph . Active investigations in this field are being carried out in Germany, in Professor R. Take s laboratory. [Pg.349]


See other pages where Sila-Pharmaca is mentioned: [Pg.3]    [Pg.26]    [Pg.45]    [Pg.57]    [Pg.66]    [Pg.1159]    [Pg.3]    [Pg.26]    [Pg.45]    [Pg.57]    [Pg.66]    [Pg.1159]   


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