Significant harm

No significant harmful health effects to humans or animals are expected from exposure to this pathogen unless the individual has a compromised respiratory system or suppressed immune system. Direct contact with large quantities of B. subtilis spores may cause redness or irritation of the skin. 

No significant harmful health effects to humans or animals are expected from exposure to this pathogen. 

Critical loads and levels are measurable quantitative estimates showing the degree of tolerable exposure of receptors to one or more pollutants. According to present knowledge, when this exposure remains below the critical load and level thresholds, significant harmful effects on specified receptors do not occur (Gregor, 2003). They serve as reference points against which pollution levels can be compared and potential risks to environmental components can be estimated. 

In spite of almost global attraction of the critical load concept, the quantitative assessment of critical load values is connected till now with some uncertainties. The phrase significant harmful effects in the definition of critical load is of course susceptible to interpretation, depending on the kind of effects considered and the amount of harm accepted (De Vries and Bakker, 1998a, 1998b). Regarding the effects considered in terrestrial ecosystems, a distinction can be made in effects on ... 

Special guidance for exposures often in excess of dose limits is required for emergency response operations. In severe disasters, prompt but well considered actions can potentially save lives and avert significant harm to the public. NCRP Report 116 titled Limitations of Exposure to Ionizing Radiation2 provides broad guidance for emergency responders. 

These events are significant because they may result in significant harm and even death to a patient and can also pose serious detriments to pharmacists, such as feelings of guilt and stress, the potential for litigation from patients and their families, the threat... 

Similarly, hypothermia has known effects on cardiac rhythm, electrolyte balance, and metabolism, all of which could be enhanced when combined with pharmaceutical agents such as calcium or other ion channel blockers. Thus, as with all possible treatments, there is the potential not only for improvement, but also significant harm if an inappropriate combination is employed. 

Dependence refers to any one or the combination of cognitive, behavioral, and physical symptoms that indicate that the individual continues to use the substance in spite of significant harm or life problems. Typically a person who has substance dependence also experiences tolerance and withdrawal, as well as compulsive use and drug-seeking behavior. 

Activities tliat result in significant harm to tlie enviromnent... 

Critical loads are quantitative estimates of the exposure to one or more pollutants below which significant harmful effects on specified sensitive components of the environment do not occur, at least according to present knowledge (Nilsson and Greenfelt, 1988). The exceedance of critical loads for impacts on soils and surface waters have been the basis of negotiations for emission reductions in Europe. The concept of critical loads has spread to Canada but not to the United States. The steady-state model for critical loads implies that only the final results of a certain deposition level are considered. The time required... 

---