Siegrist reactions

Siegrist Reaction. Double bonds can be synthesized by a variety of base-catalyzed condensations between an active methylene compound and a carbonyl group. Meier et al. [895, 896] used a base-catalyzed self-coupling of the Schiff bases of various p-methylbenzaldehydes to prepare PPV. 

H. Meier, H. Kretzshmann, and M. Lang, Synthesis of 2-alkoxy substituted oligo and poly( 1,4-phenylene-ethylene)s and 2-arylbenzo[/ ]furanes by applying the Siegrist reaction,5. Pra/c Chem. 336. 1 (1994). 

This volume contains two articles which bring up to date older reviews in the Series. Progress in the chemistry of the 1,3-oxazines since they were covered by Eckstein and Urbanski in Volume 2 (1963) is described by the same authors. Acheson and Elmore review reactions of acetylenecarboxylic esters with nitrogen heterocycles, which have been the subject of much concentrated research in the years since Acheson s article in Volume 1. The review on indolizines (Swinboume, Hunt, and Klinkert) also concentrates on the advances of the last IS years and up-dates reviews published elsewhere. Anastassiou and Kasmai provide a critical account of the V-excessive heteroannulenes, and Fletcher and Siegrist deal authoritatively with the olefin-forming condensations of anils with methyl groups, the Anil Synthesis. ... 

Shankar G, Shores E, Wagner C, Mire-Sluis A (2006) Scientific and regulatory considerations on the immunogenicity of biologies. Trends Biotechnol 24 274-280 Siegrist CA (2007) Mechanisms undta-lying adverse reactions to vaccines. J Comp Pathol 137 (Suppl 1) S46-S50... 

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