Sickle-cell haemoglobin

Ingram, V.M. Gene mutation in human haemoglobin the chemical difference between normal and sickle cell haemoglobin. Nature 180 326-328, 1957. 

R38. Russo, G., and Mollica, F., Sickle cell haemoglobin and two types of thalassemia in the same family. Ada Haematol. 28, 329-340 (1962). 

Watson-Williams, E. J., Beale, D., Irvine, D., and Lehmann, H., A new haemoglobin, D Ibadan (5-87 Threonine Lysine), producing no sickle-cell haemoglobin D disease with haemoglobin S. Nature (London) 205, 1273-1276 (1965). 

Mechanisms to control parasitic protozoa are similar to those utilized for other infectious agents they can be divided into non-specific mechanism(s) and specific mechanism(s) involving the immune system. The best studied non-specific mechanisms include those that affect the entry of parasites into the red blood cell. The sickle cell haemoglobin trait and lack of the Duffy factor on the erythrocyte surface make the red cell more resistant to invasion by Plasmodium. These traits are commonly found in populations from malaria-endemic regions. A second example of a non-specific factor is the presence of trypanolytic factors in the serum of humans which confer resistance to T. brucei, Although nonspecific factors can play a key role in resistance, usually they work in conjunction with the host s immune system. 

Ingram, V. M- 1957. Gene mutation in human hemoglobin The chem ical difference between nonnal and sickle cell haemoglobin. Natun ... 

A correlative study of A B O blood groups, sickle cell haemoglobin and glucose-6-phosphate dehydrogenase deficiency as genetic marker in Mahar community of rural population of Wardha District in Maharashtra. 

Frequency of glucose-6-phosphate dehydrogenase deficiency in individuals with normal and sickle cell haemoglobin—a preliminary study. 

Beaven, G. H., and White, J. C. 1953. Detection of foetal and sickle-cell haemoglobins in human anaemias. Nature 172, 1006. 

Ingram, V. (1958) Abnormal human haemoglobins I The comparison of normal human and sickle-cell haemoglobins by fingerprinting . Biochem. Biophys. Acta, 28, 539-545. 

This phase separation was subsequently observed in a variety of systems with the common feature that they contain rod-like colloidal particles dispersions of colloidal P-FeOOH52,53 and y-AlOOH particles, dispersions of tobacco mosaic virus >57 and the rod-like bacterial viruses fd and PfP9, solutions of deoxygenated sickle-cell haemoglobin O, dispersions of cellulose microcrystals and quite recently in dispersions of poly(tetrafluoroethylene) microcrystals. ... 

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