Siastatin neuraminidase inhibitor

Neuraminidase Inhibitors — Siastatin B and Derivatives. Siastatin B, which can be regarded as a glycosyl acetamide of a branched chain 5-amino-5-deoxypentose, was isolated from a Streptomyces culture [204] and was subsequently shown, by total synthesis, to be 77 (Figure 9.24) [205]. 

Nishimura, Y, Wang, W, Kondo, S, Aoyagi, T, Umezawa, H, Siastatin B, a potent neuraminidase inhibitor the total s3mthesis and absolute configuration, J. Am. Chem. Soc., 110, 7249-7250, 1988. 

Siastatin B (40), the first natural inhibitor of neuraminidase and a compound that also inhibits -D-glucuronidase, was discovered in 1974 [139]. Two total syntheses of this compound have been published to date [140,141]. Due to the fact that recent studies have shown that human tumours are associated with... 

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