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Short tandem repeat polymorphism STRP

There are several major types of DNA sequence variation in the human genome. One type comprises repeated sequences with variations in the number of repeat units, such as short tandem repeat polymorphisms (STRPs, also known as microsatellites) in the form of mono-, di-, tri-, and tetra-nu-cleotide repeats, or more complex sequence repeats such as variable number tandem repeats (VNTRs) [2-4]. Repeat polymorphisms are relatively... [Pg.486]

A third type of polymorphism is due to tandem repeats of short sequences that can be detected by PCR-based analysis. These are known variously as microsatellites, short tandem repeats (STRs), STR polymorphisms (STRPs), or short sequence length polymorphisms (SSLPs). These repeat sequences usually consist of two, three, or four nucleotides and are plentiful in most organisms. All PCR-converted STR markers (those for which a pair of oligonucleotides flanking the polymorphic site suitable for PCR amplification of the locus has been designed) are considered to be STSs. The advent of PCR-based analysis quickly made microsatellites the markers of choice for mapping. [Pg.114]


See other pages where Short tandem repeat polymorphism STRP is mentioned: [Pg.329]    [Pg.663]    [Pg.565]    [Pg.329]    [Pg.663]    [Pg.565]    [Pg.329]    [Pg.768]   
See also in sourсe #XX -- [ Pg.11 , Pg.49 ]




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