Short-chain dehydrogenase/ reductases SDRs

DFR belongs to the single-domain-reductase/epimerase/dehydrogenase (RED) protein family, which has also been termed the short chain dehydrogenase/reductase (SDR) superfamily. This contains other flavonoid biosynthetic enzymes, in particular the anthocyanidin reductase (ANR), leucoanthocyanidin reductase (EAR), isoflavone reductase (IFR), and vestitone reductase (VR), as well as mammalian, bacterial, and other plant enzymes. ... 

H Jornvall, B Persson, M Krook, S Atrian, R Gonzalez-Duarte, J Jeffery, D Ghosh. Short-chain dehydrogenases/reductases (SDR). Biochemistry 34 6003-6013,1995. 

Dehydrogenase activity could clearly be separated from a ketosteroid iso-merase (see below) indicating that rDZ3 3-HSD is related to microbial HSDs of the short-chain dehydrogenase/reductase (SDR) family but not with mammalian HSDs, which are multifunctional enz)mies. 

In discussions on the mechanisms of the enzymes involved in each pathway, there will be a particular focus on three superfamilies enzymes that share the thiolase fold and catalyze carbon—carbon bond formation and cleavage reactions catalyzed by NAD(P)-dependent enzymes in the fatty acid biosynthesis pathway involve proteins that are members of the short-chain dehydrogenase reductase (SDR) superfamily and finally there are mechanistic parallels between the hydration and dehydration reactions in each pathway with a particular focus on the crotonase superfamily. 

JOrnvall, H., Persson, B., Krook, M., Atrian, S., Gonzalez-Duarte, R., Jeffery, J. Ghosh, D. (1995) Biochemistry, 34, 6003-6013, Short-chain dehydrogenases/reductases (SDR). 

Abbreviations. ADH, alcohol dehydrogenase ALDH, aldehyde dehydrogenase AKR, aldo-keto reductases GST, glutathione -transferase MT, methyltransferase SDR, short-chain dehydrogenases/reductases SULT, sulfotransferase UGT, UDP-glucuronosyltransferase. 

Egerer-Sieber et al. (2006) reported on the purification and crystallization of recombinant 5p-POR from D. lanata. Later on, Gavidia et al. (2007) predicted that the 5p-POR belongs to the SDR family (Oppermann et al, 1997). Finally, Thorn et al. (2008) fully characterized the crystal structure and found that the progesterone reductase from D. lanata defines a novel class of short-chain dehydrogenases / reductases. 

Kavanagh, K. L., Jornvall, H., Persson, B., Oppermann, U. (2008). Medium- and short-chain dehydrogenase/reductase gene and protein families the SDR superfamily functional and structural diversity within a family of metabolic and regulatory enzymes. Cellular and Molecular Life Sciences, 65, 3895—3906. 

SDR Short-chain dehydrogenase-reductase StAR Steroidogenic acute regulatoiy protein... 

Short-chain DHRSl Dehydrogenase/reductase (SDR family) member 1 14ql2... 

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